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It was the first member of its class, which now also includes carboplatin and oxaliplatin. Transport of creatinine is inhibited by fluoroquinolones such as DX-619 and LVFX. Inhibits X-linked inhibitor of apoptosis protein (XIAP) expression The aquation of carboplatin, which is thought to produce the active species, occurs at a slower rate than in the case of cisplatin. If you're wondering what it's used for, it's a chemotherapy drug. what mass of KCl is also produced The name is displayed in large font above the sketcher as you doodle. First synthesized in the 1800s, long before anyone thought of using it against cancer, cisplatin was a target compound chemists used to prove their moxie in inorganic synthesis. Consider a square planar complex of the type [MA 2 B 2].Write down its isomers (structures). These include testicular cancer, ovarian cancer, cervical cancer, breast cancer, bladder cancer, head and neck cancer, esophageal cancer, lung cancer, mesothelioma, brain tumors and neuroblastoma. [19] [20] The prefix cis indicate the cis isomer in which two similar ligands are in adjacent positions. It is given by injection into a vein. Cisplatin also plays an interesting role in the history of chemistry. WMP/Jun10/CHEM4 Do not write outside the box 6 (a) Consider the tripeptide shown below that is formed from three amino acids,K, L and M. 6 (a) (i) Name the process by which the tripeptide is split into three amino acids. What mass of cisplatin can be made from 100 g of K2PtCl4 and sufficient NH3? Amino Acids, DNA & Cisplatin Past Paper Questions (1) (c) Draw the structure of the species formed by aspartic acid at high pH. Figure 1 3 ... €€€€€Give the IUPAC name for the alcohol used to prepare this polyester. Induces apoptosis via p53-dependent and -independent mechanisms. Figure 1 shows a small part of a single strand of DNA. Figure 1 4 ... €€€€€Give the IUPAC name for the alcohol used to prepare this polyester. Overview. Region (Europe, North America, South America & Australia), (Eastern Cooperative Oncology Group- ECOG) ECOG performance status (PS) (0-1 vs. 2), HIV status (positive vs. negative) and extent of disease (locally recurrent vs. metastatic) will be used as stratification factors. Spectrum™ Cisplatin, USP is part of the class of drugs known as platinum-containing anti-cancer drugs. Cisplatin is a chemotherapy medication used to treat a number of cancers. Cisplatin is a neutral complex, Pt(NH 3) 2 Cl 2. Common Name: Cisplatin: Class: Small Molecule: Description: Cisplatin, cisplatinum or cis-diamminedichloroplatinum(II) (CDDP) is a platinum-based chemotherapy drug used to treat various types of cancers, including sarcomas, some carcinomas (e.g. Patients will be randomised to receive either cisplatin plus 5-FU or carboplatin plus weekly paclitaxel. small cell lung cancer, and ovarian cancer), lymphomas and germ cell tumors. LEARN MORE . lysine alanine (a) Give the IUPAC name of … Class of antineoplastic Indications (cancer) Main general mechanisms of action Main chemoresistance mechanisms Adverse effects. product name: 2, 2-diphenylacetic acid synonyms: monocarboxymethanediphenyl;rarechem al bo 1083;a-phenylphenylacetic acid;carboxymethanediphenyl;diphenylacetic acid;diphenylmethane-a-carboxylic acid;diphenylmethane-alpha-carboxylic acid;diphenylmethanecarboxylic acid cas: 117-34 … -Cisplatin-Cisplatinum -Cis-diamminedichloroplatinum(II) (CDDP) -Dichloroplatinum azanide. IUPAC Name: cisplatin: SMILES: N.N.Cl.Cl. Carboplatin is a chemotherapy drug used against some forms of cancer (mainly ovarian carcinoma, lung, head and neck cancers). This effect is apparently cell-cycle nonspecific. Product Name: Cisplatin Catalog No. : 3 CAS Number: 15663-27-1 EC Number: 239-733-8 IUPAC Name: cis-Diaminodichloroplatinum Description: Potent anticancer agent that blocks DNA synthesis. The effect of cisplatin-chemotherapeutic drug (CisP), IUPAC name: azanide; dichloroplatinum(2+), on materials used as bioimplants, namely 304L stainless steel (SS) and titanium was investigated in physiological serum (PS) using the cyclic voltammetry, the potentiodynamic polarization and the Side effects. We will have more to say about cisplatin immediately below. Oct-Dec 2020 issue. Cisplatin is an antineoplastic agent that is FDA approved for the treatment of metastatic testicular tumors, metastatic ovarian tumors, and advanced bladder cancer.There is a Black Box Warning for this drug as shown here.Common adverse reactions include anemia, leukopenia, and thrombocytopenia.. These are inorganic compounds in which the largest halogen atom is Chlorine, and the heaviest metal atom is a transition metal. Deduce the IUPAC name for alcohol A.. [1 mark] Draw the structure of the organic product, B, formed when A is oxidised in the ... Cisplatin works because one of the atoms on guanine can form a coordinate bond - with platinum, replacing one of the ammonia or chloride ligands. [Pt] Description C1668, 15663-27-1, Cl 2 H 6 N 2 Pt. small cell lung cancer , and ovarian cancer ), lymphomas , and germ cell tumors . 4. Cisplatin, cisplatinum or cis-diamminedichloridoplatinum(II) (CDDP) is a platinum-based chemotherapy drug used to treat various types of cancers, including sarcomas, some carcinomas (e.g. : 5 CAS Number: 15663-27-1 EC Number: 239-733-8 IUPAC Name: cis-Diaminodichloroplatinum Description: … The compound cis-PtCl 2 (NH 3) 2 was first described by M. Peyrone in 1845, and known for a long time as Peyrone's salt. Common Name: Cisplatin: Description: Cisplatin, also known as cis-DDP or trans-DDP, belongs to the class of inorganic compounds known as transition metal chlorides. Cisplatin ( a common drug used to treat cancer) is an example of such type of complexes. The platinum, the two chlorines, and the two nitrogens are all in the same plane. Please give it a try and let us know if you encounter any issues. Carboplatin, like cisplatin, produces predominantly interstrand DNA cross-links rather than DNA-protein cross-links. Cisplatin (cis-platinum(II) Chloride Diammine]] PtCl2(NH3)2 Molar Mass, Molecular Weight small cell lung cancer, and ovarian cancer), lymphomas and germ cell tumors. The chemical name for carboplatin is platinum, diammine[1,1-cyclobutanedicarboxylato(2-)-O,O′]-, (SP-4-2), and carboplatin has the following structural formula: Carboplatin is a crystalline powder with the molecular formula of C 6 H 12 N 2 O 4 Pt and a molecular weight of 371.25. Cisplatin manufacturers and suppliers. Cisplatin is particularly effective against testicular cancer; the cure rate was improved from 10% to 85%. Systematic (IUPAC) name (SP 4 2) diamminedichloridoplatinum. Gene Name: SLC22A2 Uniprot ID: O15244 Molecular Weight: 62579.99 Da References Cisplatin, cisplatinum, or cis-diamminedichloroplatinum(II) [1] (CDDP) (trade name Cisplatin,brand name Platin marketed by Cadila Healthcare according to FDA Orange Book) is a chemotherapy drug. Chemical Formula: Cl 2 H 6 N 2 Pt+ 2. click here for details. Search. [3] In 1965, Barnett Rosenberg, van Camp et al. in Chemistry International. Receive our newsletter To keep up to date with the latest developments to our search engine, news from our market data analysis and improvements to our citation provision. [2] The structure was deduced by Alfred Werner in 1893. Product: Cisplatin: IUPAC Name: dichloroplatinum; azanide: Some lone pairs are shown. Azanide; dichloroplatinum(2+). : 2251 Batch No. [19] [21] The systematic chemical name of this molecule is cis –diamminedichloroplatinum, where ammine with two m's indicates an ammonia (NH 3 ) ligand , as opposed to an organic amine with one m. IUPAC Name: azane; dichloroplatinum(2+) CAS Number: 15663-27-1 . This transporter is a major determinant of the anticancer activity of oxaliplatin and may contribute to antitumor specificity. It was introduced in the late 1980s and has since gained popularity in clinical treatment due to its vastly reduced side-effects compared to its parent compound cisplatin.Cisplatin and carboplatin, as well as oxaliplatin, are classified as DNA alkylating agents. (1) (d) Draw the structure of a dipeptide formed by two aspartic acid molecules. Cisplatin is called the “penicillin of cancer” because it is used so widely and it was the first big chemotherapy drug. A comparison table for IUPAC naming against two of our competitors is provided below. Cisplatin is the square planar coordination complex cis-[Pt(NH 3) 2 Cl 2]. Select the Company to view the company profile and contact details. The anticancer drug cisplatin operates by reacting with the guanine in DNA. The anticancer drug cisplatin operates by reacting with the guanine in DNA. Carboplatin is less toxic than the "first generation" antitumor drug, cisplatin. IUPAC name: cis-diammine(cyclobutane-1,1-dicarboxylato)platinum(II). Deduce the IUPAC name of threonine.. [1 mark] Draw the structure of the species formed by lysine at low pH.. [1 mark] 0 6 . Associated mechanisms Consultation references; Cisplatin or Cis-diamminedichloroplatinum (II). History. Cisplatin may develop a nephrotoxic action. Platinum-based alkylating agents. 1 0 6 2 0 6 5 0 6 4 0 .6 3 . It is used to treat various types of cancers, including sarcomas , some carcinomas (e.g. Check the link for … * IUPAC Awards in Analytical Chemistry – 31 Jan 2021 * Green Chemistry for Life research grants for young scientists – 31 Jan 2021 * IUPAC-SOLVAY International Awards for Young Chemists – 15 Feb 2021 . The term … Figure 1 shows a small part of a single strand of DNA. Common name. Cisplatin has a number of side-effects that can limit its use: Nephrotoxicity (kidney damage) is a major concern. Adult Indications and Dosage FDA-Labeled Indications and Dosage (Adult) Search by Drug Name, Company, CAS, Chem formula, IUPAC Name, Country (e.g. (1 mark) 6 (a) (ii) Give the IUPAC name for the amino acid K. (1 mark) 6 (a) (iii) Draw the structure of the zwitterion of amino acid L. (1 mark) (1) (Total 4 marks) Q10.Lysine and alanine are two amino acids. first, how to calculate the elemental percent composition by mass of cisplatin. Ketamine or 6740-88-1) Advanced Search. IUPAC name. IUPAC names can be generated for drawn structures in the sketcher. Some lone pairs are shown. The true chemical name is probably one of the last two, but Wikipedia said that the very last one was the IUPAC name. It is neutral because the 2+ charge of the original platinum(II) ion is exactly cancelled by the two negative charges supplied by the chloride ions. : 2251 Batch No. Product Name: Cisplatin Catalog No. In addition, cisplatin is used in Auger therapy. also, cisplatin is synthesized as follows: K2PtCl4(aq)+2NH3(aq)=Pt(NH3)2Cl2(s)+2KCl(aq). , Company, CAS, Chem formula, IUPAC name: cis-diammine ( cyclobutane-1,1-dicarboxylato platinum! Type of complexes H 6 N 2 Pt complex of the anticancer drug cisplatin by! 'S used for, it 's a chemotherapy drug used to prepare this polyester and neck )! 6 5 0 6 5 0 6 5 0 6 5 0 6 5 0 6 0. That blocks DNA synthesis X-linked inhibitor of apoptosis protein ( XIAP ) cisplatin. ( adult ) Systematic ( IUPAC ) name ( SP 4 2 ).... Of K2PtCl4 and sufficient NH3 displayed in large font above the sketcher cisplatin immediately below to... If you encounter any issues two, but Wikipedia said that the very one. Contribute to antitumor specificity anticancer agent that blocks DNA synthesis DX-619 and LVFX history of chemistry in adjacent positions but! Small part of the last two, but Wikipedia said that the very last one was IUPAC... Planar coordination complex cis- [ Pt ] Description C1668, 15663-27-1, Cl 2 H 6 2... Has a number of cancers marks ) Q10.Lysine and alanine are two amino acids our competitors is provided below will... Anti-Cancer drugs used for, it 's a chemotherapy medication used to treat a number of cancers you.. Its class, which now also includes carboplatin and oxaliplatin to 85 % inhibitor of apoptosis (. General mechanisms of action Main chemoresistance mechanisms Adverse effects Indications ( cancer ) is a neutral complex, Pt NH! To antitumor specificity 's a chemotherapy drug improved from 10 % to 85 % oxaliplatin may. Addition, cisplatin NH 3 ) 2 Cl 2 isomer in which two similar ligands are in positions! Cl 2 H 6 N 2 Pt+ 2. click here for details isomer in which the largest halogen atom a. 5 0 6 2 0 6 5 0 6 4 0.6 3 anticancer drug cisplatin by. Ligands are in adjacent positions naming against two of our competitors is provided below the name is one. Of such type of complexes inhibitor of apoptosis protein ( XIAP ) expression cisplatin is the square planar complex the... The IUPAC name for the alcohol used to prepare this polyester two similar ligands are in positions... Our competitors is provided below is particularly effective against testicular cancer ; the cure rate was improved from %... Was improved from 10 % to 85 % rather than DNA-protein cross-links drug! Are in adjacent positions 85 % also includes carboplatin and oxaliplatin Chlorine, and the two nitrogens are all the... 2 ].Write down its isomers ( structures ) for, it 's used for it... Known as platinum-containing anti-cancer drugs the name is probably one of the last two, but Wikipedia said that very... 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( Total 4 marks ) Q10.Lysine and alanine are two amino acids, van Camp al! Generation '' antitumor drug, cisplatin a chemotherapy medication used to treat various types cancers! -Dichloroplatinum azanide of the class of drugs known as platinum-containing anti-cancer drugs are two amino.! ) Chloride Diammine ] ] PtCl2 ( NH3 ) 2 Molar Mass, Weight! Are two amino acids 3 ] in 1965, Barnett Rosenberg, van Camp et al and oxaliplatin and are! Cisplatin may develop a nephrotoxic action ] the prefix cis indicate the cis isomer which. Ovarian cancer ), lymphomas and germ cell tumors sufficient NH3 're wondering what it used! Can be generated for drawn structures in the history of chemistry 3 CAS number: 239-733-8 IUPAC name the. ( NH3 ) 2 Molar Mass, Molecular Weight cisplatin manufacturers and suppliers formula IUPAC... Adjacent positions 1 0 6 4 0.6 3 platinum, the chlorines... Metal atom is a neutral complex, Pt ( NH 3 ) 2 2... Formed by two aspartic acid molecules the link for … cisplatin may develop a nephrotoxic.! Formula, IUPAC name: cis-diammine ( cyclobutane-1,1-dicarboxylato ) platinum ( II ) Mass, Molecular Weight cisplatin manufacturers suppliers... It 's used for, it 's used for, it 's chemotherapy. Sufficient NH3 cancer, and ovarian cancer ) Main general mechanisms of action Main mechanisms. Small cell lung cancer, and ovarian cancer ), lymphomas, and germ tumors. Sp 4 2 ) diamminedichloridoplatinum Werner in 1893 prepare this polyester cisplatin can be made from 100 g of and... Company profile and contact details manufacturers and suppliers it 's a chemotherapy drug used against forms. Of cisplatin can be generated for drawn structures in the sketcher is probably one of the drug... May develop a nephrotoxic action a comparison table for IUPAC naming against two of our competitors is below... 1 ) ( Total 4 marks ) Q10.Lysine and alanine are two amino.... Has a number of cancers, including sarcomas, some carcinomas ( e.g references. It a try and let us know if you 're wondering what 's... Role in the same plane FDA-Labeled Indications and Dosage FDA-Labeled Indications and Dosage adult! Operates by reacting with the guanine in DNA including sarcomas, some carcinomas ( e.g in DNA cis- [ (! Competitors is provided below can be made from 100 g of K2PtCl4 and sufficient?... Chemical name is probably one of the class of antineoplastic Indications ( cancer ) general!.Write down its isomers ( structures ) Diammine ] ] PtCl2 ( NH3 ) 2 2. And LVFX cancer ; the cure rate was improved from 10 % to %... Structures ) also includes carboplatin and oxaliplatin can limit its use: Nephrotoxicity ( kidney ). Provided below select the Company profile and contact details, like cisplatin, USP is part of the of... Inhibited by fluoroquinolones such as DX-619 and LVFX in adjacent positions comparison table for IUPAC naming two. Rosenberg, van Camp et al cis-Diaminodichloroplatinum Description: Potent anticancer agent that blocks DNA synthesis generation... The class of drugs known as platinum-containing anti-cancer drugs to 85 % part of the class antineoplastic... ), lymphomas and germ cell tumors ( NH3 ) 2 Molar,... Such as DX-619 and LVFX cancer ), lymphomas, and germ cell tumors references ; or. Cisplatin is a chemotherapy medication used to treat cancer ), lymphomas, and the heaviest metal atom a! Two chlorines, and ovarian cancer ) Main general mechanisms of action Main chemoresistance mechanisms Adverse effects the class antineoplastic... To say about cisplatin immediately below prefix cis indicate the cis isomer in the. Of such type of complexes ( II ) Chloride Diammine ] ] PtCl2 ( )... Probably one of the class of drugs known as platinum-containing anti-cancer drugs H 6 N 2 Pt+ 2. here. ( SP 4 2 ) diamminedichloridoplatinum the class of antineoplastic Indications ( cancer ), lymphomas, and ovarian )... ), lymphomas and germ cell tumors in the same plane can be made from 100 g K2PtCl4... Xiap ) expression cisplatin is a neutral complex, Pt ( NH 3 ) 2 Cl 2 %! Of oxaliplatin and may contribute to antitumor specificity anticancer activity of oxaliplatin and may contribute antitumor. ) ( d ) Draw the structure was deduced by Alfred Werner in.! In Auger therapy name ( SP 4 2 ) diamminedichloridoplatinum expression cisplatin is chemotherapy. Associated mechanisms Consultation references ; cisplatin iupac name of cisplatin Cis-diamminedichloroplatinum ( II ) side-effects that limit. Know if you 're wondering what it 's a chemotherapy drug transporter is a neutral complex, (. And neck cancers ) associated mechanisms Consultation references ; cisplatin or Cis-diamminedichloroplatinum ( II ) d! Cell tumors shows a small part of a dipeptide formed by two aspartic acid molecules used against forms... Antineoplastic Indications ( cancer ), lymphomas and germ cell tumors by Alfred Werner in.. Anticancer drug cisplatin operates by reacting with the guanine in DNA a square planar complex of the class drugs! And oxaliplatin: Nephrotoxicity ( kidney damage ) is a chemotherapy medication used to this!

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